Monday , October 22 2018

Alli

Generic Name: orlistat (OR li stat)

Brand Names: alli, Xenical

 

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Description

Medications for obesity treatment can be separated into the following groups:

 

Suppressing appetite and reducing food intake;
Increasing energy consumption;
Reducing absorption of substances;

 

Alli belongs to the last group mentioned here. Its active substance, orlistat, blocks the activity of pancreatic and intestinal lipase, which disrupts the cleavage of fats and reduces their absorption in the intestine. These pills help to reduce and maintain body weight, normalize lipid and carbohydrate metabolism. The important condition is that this is a drug for long-term use. Treatment should last for nearly 2 years.

 

Pharmacological Effect

 

Alli is a lipase inhibitor. When administered, orlistat inhibits gastric and pancreatic lipases. As a result, the cleavage of food fats is violated and their absorption from the digestive tract decreases. When the drug is used systematically by patients with obesity, this effect leads to reduction of body weight. Orlistat is practically not absorbed from the digestive tract. and that’s why it does not cause any resorptive effect.

 

Among its indications for use is obesity (in a combination with a low-calorie diet and moderate physical trainings).

 

Use during Pregnancy

 

Adequate and well-controlled studies of orlistat usage by pregnant women have not been conducted yet. Since animal test data may not always predetermine the same response in humans, orlistat is not recommended to be used during pregnancy. Also, it is not recommended to lose weight during pregnancy with any other medication. It is not known at the moment, whether orlistat is secreted into the breast milk, and it shouldn’t be administered by nursing women as well. Please, contact your doctor before taking Alli while you are breastfeeding.

 

Contraindications For Use

 

Hypersensitivity;
Chronic malabsorption syndrome;
Cholestasis.

 

Side Effects

 

Side effects are possible, and they may include the following:

 

Oily excretions from the rectum;
Flatulence;
“Fat” stools;
Frequent defecation;
Urgent urges for defecation, etc.

 

Dosage

 

Take 120 mg of Alli during each main meal or within an hour after a meal, usually no more than 3 times a day. If your food contains no fats or a really small amount of fat, you can skip the intake.

 

It is proven that orlistat leads to decrease in absorption of betacarenol, α-tocopherol from the gastrointestinal tract.

 

Special Instructions for Usage

 

It should be borne in mind that the frequency and severity of side effects increase with an increase in the content of fat in the diet. With its decrease, the incidence of side effects decreases as well. It is recommended to evenly distribute the amount of fat consumed per day among your daily meals.

 

In the process of treatment, as the body weight decreases, it is possible to improve the state of such obesity-related pathological processes as the following:

 

Arterial hypertension;
Diabetes mellitus;
Lipid metabolism disorders.

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