Hydrea is a medication used by patients suffering from sickle cell anemia and several types of cancer. Before starting the treatment course it is important to consult a healthcare professional or read detailed safety guide to eliminate dangerous complications.
Indications for use:
Chronic myelogenous leukemia;
True polycythemia (erythremia);
Malignant tumors of the head and neck, except for lip cancer (in a combination with radiation therapy);
Cervical cancer (in a combination with radiotherapy).
Hypersensitivity to hydroxycarbamide or any other auxiliary substance included in the drug;
Pregnancy and breastfeeding;
Leukopenia below 2,500;
Child age (safety and efficacy are not established).
You should take the remedy carefully if you have any of the following conditions:
Hepatic and/or renal failure;
Severe anemia (should be compensated before treatment);
Radiotherapy, chemotherapy (after surgery) (because of a possibility of myelosuppression, exacerbation of radiation erythema);
Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
Ways of Intake and Overdose
When choosing the regimen and doses in each individual case, you should be guided by special data. The drug is used orally. If swallowing is difficult, the capsule can be opened. Pour the contents into a glass of water and immediately drink it. You should take a fairly large amount of fluid during treatment with the drug.
When using the drug in doses which are several times higher than recommended, patients can get the following signs of acute dermatological toxicity:
Edema followed by peeling of the palms and feet;
Intense generalized hyperpigmentation of the skin and stomatitis.
When there is simultaneous use of the drug with other myelosuppressive medications or radiation therapy, the degree of suppression of bone marrow function or development of other side effects may increase.
Treatment with Hydrea should be carried out only under the doctor’s supervision, who has experience in use of antitumor therapy. Before each course and during treatment with the drug, it is necessary to periodically monitor functions of the bone marrow, kidney and liver. Determination of hemoglobin, leukocytes and platelets should be carried out at least once a week during the entire period of treatment with the drug.
Usage during Pregnancy and Lactation
Hydrea should not be taken during pregnancy, so during the therapy a patient should be warned about the need for reliable contraception. If pregnancy has occurred during the drug administration, it is necessary to warn the patient about the possibility of a risk to a fetus. The drug passes into breast milk, so it is necessary to stop breastfeeding for the period of treatment or cancel the therapy.