Lioresal is a popular medication available in its injectable and oral forms. Nowadays, it’s taken by patients to relax their skeletal muscles (they move the skeleton and can be called striated muscles). Chemically, this medicine is related to GABA, which is a naturally occurring and important brain neurotransmitter. When GABA is released by certain nerves, it caused the activity and functions of other nerves to reduce.
It’s believed that Lioresal acts as GABA, and it works by blocking the activity of nerves in the brain part that control the relaxation and contraction of skeletal muscles. Its intake was approved by the FDA in 1977, and now many doctors prescribe this medication to treat such conditions as spasms of skeletal muscles, muscle rigidity, clonus and pain resulted by such serious diseases as multiple sclerosis. Sometimes, Lioresal is also injected into the spinal cord to manage severe spasticity.
Unwanted Mild and Serious Side Effects
Like many other drugs, Lioresal is responsible for causing certain adverse effects, but they are rare and most of them are mild and moderate. For example, patients may experience the following symptoms:
Unusual weakness and drowsiness;
Headaches and dizziness;
Vomiting and nausea;
Seizures and constipation;
Confusion and low blood pressure;
Inability to sleep and respiratory depression;
Urinary retention or increased urinary frequency.
If you notice any of these annoying signs, contact your doctor immediately, especially if any of them become persistent or get worse. Besides, abrupt discontinuation of this medication may lead to different withdrawal symptoms, such as:
Hallucinations and seizures;
Muscle rigidity and high fever;
Rebound spasticity and muscle breakdown.
That’s why patients should decrease their regular doses gradually and based on the directions given by their doctors.
Available Preparations and Common Doses
It’s possible to find Lioresal as standard tablets and injections that all come in different strengths to fit the needs of all patients. If adult patients need to treat spasticity, their regular dose is 5 mg of this drug taken 3 times a day. Based on their individual tolerance, this dosage can be increased by 5 mg, but it’s not allowed to change doses without consulting doctors.
Dangerous Drug Interactions
It’s not advisable to take this medication with other pills that work by depressing the functions of nerves, because this combination may result in extra reduction of brain functioning. There are some other meds that shouldn’t be taken with Lioresal, including tricyclic antidepressants, because they lead to additional muscle weakness. Don’t take this medicine with any MAO inhibitors, because you risk ending up with dangerous drug interactions. This treatment may also require the adjustment of antidiabetic meds.